The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells: ##STR00001## wherein W, Cyc, p, Y, X, Z, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, i and n are as defined for Formula (I) herein. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia.