A time domain sampling technique for a CMOS imager enables a wide dynamic range and flexibility by employing up to two-degrees of freedom during such sampling. Two degrees of freedom can be achieved by making one or both of an integration time and a reference (e.g., voltage or current) variable during sampling. The sampling (or image capture) is implemented by associating a time with when a pixel has a desired value relative to the reference in response to the pixel receiving incident light. The reference can be fixed or variable during different portions of the sampling, and further can be programmable to implement a desired sampling pattern for a given application.