A device for the collection of oral fluid from a subject's oral cavity may
include a sample-collecting mouthpiece and a one-way valve. The
mouthpiece may include a collecting chamber, introducible into the oral
cavity of the subject for collecting oral fluid, and a resiliently
deformable wall section defining at least part of the collecting chamber
such that compression of the resiliently deformable wall forcibly expels
a collected fluid from the collecting chamber via a collecting chamber
outlet. The one-way valve may be in fluid communication with the
collecting chamber outlet and may allow fluid to be displaced from the
device following compression of the resiliently deformable wall but
prevents ambient air flowing back through the valve into the device.