The present invention is directed toward recellularizing a devitalized
cartilage graft with viable recellularizable cells in vivo, in situ, or
in vitro to render the tissue vital. The present invention is also
directed toward repairing a cartilage defect and implanting a cartilage
graft into a human or animal by crafting a cartilage matrix into
individual grafts, disinfecting and cleaning the cartilage graft,
applying a pretreatment solution to the cartilage graft, removing
cellular debris using an extracting solution to produce a devitalized
cartilage graft, recellularizing the devitalized cartilage graft,
implanting the cartilage graft into the cartilage defect with or without
an insertion device, and sealing the implanted cartilage graft with
recipient tissue. The devitalized cartilage graft is optionally stored
between the removing cellular debris and the recellularizing steps. The
present invention is directed to both recellularized cartilage grafts as
well as a process for recellularizing cartilage grafts.