Compounds of the formula ##STR00001## or a pharmaceutically acceptable
salt thereof, wherein R.sup.1 is aryl, arylalkyl, heteroaryl,
heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl,
heterocycloalkylalkyl or alkyl, all optionally substituted; R.sup.2 is H;
or aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl,
cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl or alkyl, all
optionally substituted; R.sup.3 is aryl, heteroaryl, cycloalkyl or
heterocycloalkyl, all optionally substituted; X is a bond,
--(CH.sub.2).sub.m--N(R.sup.7)--(CH.sub.2).sub.n--,
--(CH.sub.2).sub.m--O--(CH.sub.2).sub.n--,
--(CH.sub.2).sub.m--S--CH.sub.2).sub.n--, --C(O)--, --CH(OH)--,
--C(O)N(R.sup.7)--, --C(O)N(R.sup.7)-alkylene or --N(R.sup.7)C(O)--;
R.sup.7 is H or alkyl; and m and n are each 0-6, provided that the sum of
m and n is 0-6; or a pharmaceutically acceptable salt or solvate thereof,
pharmaceutical compositions thereof, and the use of said compounds in the
treatment of cough, pain, anxiety, asthma, depression, alcohol abuse,
urinary incontinence and overactive bladder are disclosed.
