The present invention provides a method for selecting samples for digital amplifier predistortion estimation. The method may include accessing a plurality of samples. Each sample includes information associated with an input signal and a corresponding output signal of the amplifier. The plurality of samples includes at least one first sample acquired at a first time and at least one second sample acquired at a second time displaced from the first time by at least one selected time interval. The method may also include selecting a subset of the plurality of samples based on a sample distribution and determining a transfer function associated with the amplifier based on the subset of the plurality of samples. The method further includes determining a predistortion function based on the transfer function and applying the predistortion function to the input signal of the amplifier.