The invention provides a method, system, and program product for determining a gradient of a parametric yield of an integrated circuit with respect to parameters of a delay of an edge of a timing graph of the circuit. A first aspect of the invention provides a method for determining a gradient of a parametric yield of an integrated circuit with respect to parameters of a delay of an edge of a timing graph of the circuit, the method comprising: conducting a statistical timing analysis; expressing a statistical circuit delay in terms of a delay of the edge; and computing a gradient of the statistical circuit delay with respect to parameters of the delay of the edge.