An intra-modality response synthesizer analyzes and enhances central nervous system, autonomic nervous system, and effector data to evaluate subject response to stimuli. A data collection mechanism obtains response data from a subject exposed to stimuli, such as marketing and entertainment stimuli. The intra-modality response synthesizer analyzes and synthesizes a plurality of modality specific response measures from central nervous system, autonomic nervous system, and effector systems. For example, the intra-modality response synthesizer analyzes response data including neurophysiological data to evaluate the effectiveness of stimuli by analyzing interactions between multiple regions of the brain.