The present invention provides compositions, including immunogenic
compositions, comprising acetylated Tat protein of an immunodeficiency
virus. The present invention further provides antibodies that
specifically bind an acetylated Tat polypeptide. The present invention
further provides methods of inducing an immune response to an
immunodeficiency virus Tat protein in an individual. The present
invention further provides methods of inhibiting transcriptional
activation of an immunodeficiency virus in a cell of an individual.