A system and method for supporting multiple network interface cards, network addresses, or ports for a single instance of a server, such as an application server. The benefits of this are realized in various areas such as traffic isolation, traffic prioritization, network redundancy, and application segregation or virtual host support. Another benefit is the ability to allow multiple servers in a cluster to listen on the same address by using different ports. The system supports logical isolation, by allowing a server to listen on multiple ports; and physical isolation, by allowing a server to listen on multiple IP addresses.