A processor employing device-specific memory address translation. In one embodiment, a processor may include a device interface configured to receive a memory access request from an input/output (I/O) device, where the request specifies a virtual memory address and a first requestor identifier (ID) that identifies the I/O device. The processor may also include an I/O memory management unit coupled to the device interface and configured to determine whether a virtual-to-physical memory address translation corresponding to the virtual memory address is stored within an I/O memory translation buffer. The I/O memory management unit may be further configured to determine whether a second requestor ID stored within the I/O memory translation buffer and corresponding to the memory address translation matches the first requestor ID. If the first and second requestor IDs do not match, the I/O memory management unit may disallow the memory access request and to signal an error condition.