A composition for photodisinfection of the oral cavity comprising toothpaste and a photosensitizing composition encapsulated within microspheres, wherein the microspheres release the photosensitizing composition into the oral cavity upon contact with liquid and/or force and the photosensitizing composition includes a photosensitizer that upon irradiation of at least one predetermined wavelength will reduce and/or eliminate microbes in the oral cavity. The present invention also includes a method of applying the composition into the oral cavity and applying irradiation to the oral cavity at a wavelength or wavelengths absorbed by the photosensitizing composition so as to reduce or eliminate microbes in the oral cavity.