One embodiment of a thin plastic applicator (1) containing a thinner plastic bubble (2) adhering to the inner surface (3) and containing a solution of dimethyl sulfoxide with one or more local anesthetic agent. A thick plastic rib (4) provides reinforcement, separating two textured sides (5) for ease of handling. A thick plastic rim (6) is attached to an adhesive foam ring and covered with protective paper (7). Removing this paper, the applicator is adhered to a disinfected and dry treatment site, and squeezed to break the inside bubble. After sufficient time to allow penetration of the anesthetizing agent, the bubble is removed, and medication or additional anesthetic injected painlessly. This replaces currently employed less effective methods of topical anesthesia, and provides health care professionals a means of fear and pain reduction where before none was available.