The invention provides compounds of formula (I): or a pharmaceutically
acceptable salt, prodrug or solvate thereof, wherein ring B represents a
monocyclic aryl ring having six ring atoms or a monocyclic heteroaryl
ring having up to six ring atoms and containing one or more ring
heteroatoms wherein each said heteroatom is nitrogen; R2 represents a
group selected from C1-6 alkyl or aryl, which said group is substituted
by one or more fluorine groups; n is 1, 2 or 3; and R1 represents an
optionally substituted group selected from C1-6 alkyl, C5-7 cycloalkyl,
heterocycloalkyl, aryl, heteroaryl, C1-6 alkyl-aryl, C1-6
alkyl-heteroaryl, C1-6 alkyl-cycloalkyl or C1-6 alkyl-heterocycloalkyl.
Processes for their preparation; pharmaceutical compositions containing
them; and their use in the treatment of a disease condition mediated by
one or more metalloproteinase enzymes. ##STR00001##