The smart medical compliance method and system invention prevents adverse drug events through the use of protocols that uniquely identifies the patient, care provider, medication and/or medical device that is to be used with radio frequency identification (RFID). The RFID devices incorporate fail-safe locks or indicators that prevent the inadvertent or unauthorized use of medication, medical devices, or medical supplies. The system corroborates, patient, the care provider, the medical device, and the manner in which it is to be used, and authorizes the action to be undertaken through an interface on a personal digital assistant PDA over a wireless communication channel. The system also timestamps events in the equivalent of a medical black box such that records may be kept to further improve patient care and allow an analysis of procedures. In addition, the system includes interfaces to medication preparation and safe disposal. A number of smart devices that interact with the system are also described. These include smart medical containers, smart clamps, smart valves, smart syringes, smart couplers, smart pipettes, and a host of other point of care devices.