This invention relates to methods for rapid nucleic acid purification from
sources heavily contaminated with high particulate material, such as
cellular debris, and solids, including suspended solids. In particular,
this invention provides methods for rapid, quantifiable recovery and
purification of nucleic acids from a variety of sources heavily
contaminated with solids, such as small organisms, tissue samples,
samples of blood found on soil, or samples of washing from foods, which
are frequently difficult sources for nucleic acid isolation due to their
propensity to clog filters and columns. A device and kit are also
provided.