A method and apparatus of interchanging a prescribed medication with a therapeutically equivalent replacement medication includes receiving medication prescription data relating to a medication prescription for a person identifying a therapeutically equivalent replacement medication for a medication associated with the medication prescription, generating an exception for the medication if a replacement medication is identified so as to prevent the medication from being dispensed to the person until the exception is resolved, transmitting a request to replace the prescribed medication with the therapeutically equivalent replacement medication to a medical provider, and resolving the exception based on the response from the medical provider.