The present invention disclose a device for electrode positioning. The electrodes are preferably positioned in the XYZ planes for collecting and recording the signals of the cell activity. This activity is afterwards amplified, filtered, sorted and acquired into an acquisition system like a computer memory.The electrode positioning device according to the present invention enable any configuration of electrode positioning. The device is comprised of: a base which is mounted onto the head directly or indirectly using a remote adapter, movable terminal holders which are mounted on said base directly or indirectly, extend guides which are mounted on said movable terminal holders and movable electrode holders which are mounted on said extended guides. The electrodes are actuated by suitable actuating means. The terminals may be connected to the terminal holder by a ball joint or a hinge.