A modulated lighting device is applied to provide modulated illumination toward a selected region. The device comprises a light box shell, a plurality of Light Emitting Diodes (LEDs), and a plurality of modulation assemblies. The light box shell comprises at least one illumination opening, the LEDs are arranged within the shell for providing a plurality of injection light beams, and the modulation assemblies are arranged in a preset array and pivotally connected with the light box shell neighboring to the illumination opening. Each modulation assembly comprises at least one reflection element to reflect the injection light beams for generating at least one illumination light beam. Thereafter, the illuminating light beams generated from the modulation assemblies pass through the illumination opening, and each of the illuminating light beams is modulated with the neighbor illuminating light beams to provide modulated illuminating toward the selected region.