Methods, systems, and computer program products disambiguate a globally universal identifier (GUID) within a file after the file is duplicated. The method involves generating a GUID for the file, generating a location identifier that defines a unique location of the file when the GUID was generated, and storing the location identifier in association with the GUID. The method also involves opening and examining the file, determining whether the location identifier matches a current location of the file, and in response to determining that the location identifier does not match the current location, generating a new GUID and replacing the GUID with the new GUID. Additionally, the method may also involve remapping references mapped to the GUID in the file to the new GUID and resetting the location identifier to match the current location.