A grip for a fishing reel handle knob includes a tubular-shaped main wall having a longitudinally extending central axis and forming a longitudinally extending interior passage sized and shaped for receiving the handle knob and a plurality of gripping flanges extending from an exterior surface of the main wall. The main wall and the gripping flanges are each preferably formed of a resiliently flexible material so that the grip is resiliently secured to the handle knob with elastic action and the gripping flanges resiliently deform when the knob is grasped by the user.