A system, method, and computer readable medium for optimizing throughput of a stream processing system are disclosed. The method comprises analyzing a set of input streams and creating, based on the analyzing, an input profile for at least one input stream in the set of input streams. The input profile comprises at least a set of processing requirements associated with the input stream. The method also comprises generating a search space, based on an initial configuration, comprising a plurality of configurations associated with the input stream. A configuration in the plurality of configurations is identified that increases throughput more than the other configurations in the plurality of configurations based on at least one of the input profile and system resources.