A slide type guide mechanism in which an adjusting screw member for eliminating looseness can be automatically tightened. The slide type guide mechanism includes a guide 22 which is provided with a guide groove 30 having a first guide side surface 26 and a second guide side surface 28 extending along straight lines parallel to each other, a threaded hole extending from an outer side surface of the guide toward the guide groove through the first guide side surface 26 , a slide 24 which is guided by the guide groove, a screw member threadably engaged in the threaded hole and rotated so as to urge the slide in a direction from the first guide side surface toward the second guide side surface of the guide groove, a torque applying device 54 having a spring for applying to the screw member a torque by which the screw member is rotated so as to move toward the guide groove.