The present invention relates to antibodies including human antibodies and
antigen-binding portions thereof that specifically bind to c-Met,
preferably human c-Met, and that function to inhibit c-Met. The invention
also relates to human anti-c-Met antibodies and antigen-binding portions
thereof. The invention also relates to antibodies that are chimeric,
bispecific, derivatized, single chain antibodies or portions of fusion
proteins. The invention also relates to isolated heavy and light chain
immunoglobulins derived from human anti-c-Met antibodies and nucleic acid
molecules encoding such immunoglobulins. The present invention also
relates to methods of making human anti-c-Met antibodies, compositions
comprising these antibodies and methods of using the antibodies and
compositions for diagnosis and treatment. The invention also provides
gene therapy methods using nucleic acid molecules encoding the heavy
and/or light immunoglobulin molecules that comprise the human anti-c-Met
antibodies. The invention also relates to transgenic animals or plants
comprising nucleic acid molecules of the present invention.