A syringe interface is provided for attaching a syringe to an injector. The syringe includes, a first and second set of generally opposing, radially outward projecting mounting flanges, and a second set of flanges offset from the first set of mounting flanges. The syringe interface includes a first set of generally opposed slots adapted to receive therethrough the first set and second set, respectively, of mounting flanges, and a first and second set of generally opposed retaining flanges adapted to releasably engage the first and second set respectively, a set of mounting flanges, when the syringe is rotated within the syringe interface. The syringe verification mechanism includes at least one flange interaction element disposed within at least one slot of the first set of slots, and at least a first flange abutment member being positioned to prevent engagement of the second set of mounting flanges with the second set of retaining flanges unless the flange verification element interacts with at least one of the flanges of the first set of mounting flanges.