A compound of the formula (I): ##STR00001## wherein R.sup.1 represents C.sub.1 C.sub.6 alkyl, amino(C.sub.1 C.sub.6 alkyl)amino, di(C.sub.1 C.sub.6 alkyl)amino or a nitrogen-containing saturated heterocyclic; R.sup.2 and R.sup.3 are the same or different and represent hydrogen or C.sub.1 C.sub.6 alkyl; R.sup.a represents C.sub.1 C.sub.6 alkyl or C.sub.2 C.sub.6 alkenyl or together with R.sup.2 represents a C.sub.1 C.sub.3 alkylene; Arom represents aryl or heteroaryl; A represents a C.sub.1 C.sub.6 alkylene; E represents a single bond, oxygen, sulfur or R.sup.4NR.sup.4--, wherein R.sup.4 is hydrogen or C.sub.1 C.sub.7 alkenoyl; X.sup.1 and X.sup.2 are the same or different and represent oxygen or sulfur; or a pharmacologically acceptable salt or ester thereof. The compound has superior acetylcholinesterase inhibitory action and selective serotonin reuptake inhibitory action, and is useful for treating or preventing Alzheimer's disease, depression, Huntington's chorea, Pick's disease, tardive dyskinesia, compulsive disorders or panic disorders.