An inspection system based upon an imaging enclosure characterized by an enclosing body, or skin. A source of penetrating radiation and a spatial modulator for forming the penetrating radiation into a beam, are both concealed entirely within the body of an enclosure such as a shipping container for convenient operational deployment. Multiple modules, such as for providing power and for enclosing an operator console may be coupled to the imaging enclosure. An image is formed of the contents of the object based in part on the scatter signal and the relative motion signal. A detector, which may be separate or part of the scatter detector module, may exhibit sensitivity to decay products of radioactive material.