An apparatus and method of preventing a collision of vehicle in a crossroad are disclosed. The apparatus includes: an information generating unit installed at each of roads near the crossroad for generating real-time vehicle information by integrating vehicle's information including a speed and a position provided from the vehicles on each of the roads and traffic sign information; and an information collecting and providing unit for providing the traffic sign information to the information generating unit, collecting vehicles' information in real-time from the information providing means of a predetermined road near the crossroad, storing the collected information, and providing the collected information to vehicles approaching the crossroad through another roads for the vehicles to predict a collision in the crossroad.