A system for physiological monitoring and prediction. The system includes a detecting system, one or more medical devices and a remote monitoring system. The detecting system includes an adherent device configured to be coupled to a patient, the adherent device including a plurality of sensors that provide an indication of at least one physiological event of a patient and a wireless communication device coupled to the plurality of sensors and configured to transfer patient data from the plurality of sensors and one or more medical treatment devices to the remote monitoring system. The one or more medical treatment devices are coupled to the wireless communication device to communicate wirelessly with the plurality of sensors, with at least one medical treatment device being an implanted device. The remote monitoring system is coupled to the wireless communication device, wherein the remote monitoring system uses data from the sensors and the one or more medical treatment devices to determine heart failure status and predict impending decompensation of the patient.