The present invention provides a protein having a potent cell-death
inducing activity that is, a fused protein is in which a modified Bax
protein fused with GFP at the N-terminus and is further fused with a
homing signal peptide having a homing activity specific for endothelial
cells in tumor angiogenesis; a gene coding the fused protein; and a
cancer cell growth inhibitor containing the fused protein. Namely, a
fused gene containing a cell death-inducing gene acting specially on
cancer tissue, which is a fused gene having a gene encoding a homing
signal peptide sequence specific for endothelial cells undergoing
angiogenesis, a gene encoding a green fluorescent protein (GFP) and a
gene encoding .DELTA.NBax protein, which is human Bax with a deletion of
the N-terminal sequence containing the BH3 domain in this order, and a
fusion protein encoded by the fused gene.