The present invention discloses compounds which are novel antagonists for
melanin-concentrating hormone (MCH), as well as methods for preparing
such compounds. In other aspects, the invention is directed to
pharmaceutical compositions comprising such MCH antagonists as well as
methods of using them to treat obesity, metabolic disorders, eating
disorders such as hyperphagia, and diabetes. Compounds of the invention
generally have the structure: ##STR00001## where the substituents are as
defined herein.