The present invention relates to Glycoprotein VI (GPVI) fusion proteins
(GPVI-fusion proteins) comprising a tag like myc, GST, HA, FLAG, STREP
but preferably a Immunoglobulin molecule (Ig), more preferably a Fc
portion of said Ig and a protein or oligopeptide having the biological
activity of GPVI (GPVI-like protein) which is binding to collagen and
their use in methods and kits for the screening of potential agonists or
antagonists for GPVI-colagen and/or platelet-collagen interaction is
disclosed. Further, pharmaaceutical compositions and therapeutic methods
are provided comprising such GPVI-fusion proteins for the treatment of
thrombotic and cardiovascular events and disorders related to
GPVI-collagen and/or platelet-collagen interactions.