A therapeutic mattress is providing including an encasing housing a base layer and a patient support layer in a cavity of the encasing. The base layer has a foam base member and foam side panels connected to the base member. The patient support layer is provided above the base layer and has a plurality of sections or zones. In one embodiment the plurality of sections is made of an inflatable component, and another of the plurality of sections is made of a non-inflatable component. In an alternate embodiment, each of the sections contains an inflatable component. In one embodiment, the zones of the patient support surface include a head zone adjacent a head of the mattress, a foot zone adjacent a foot end of the mattress, a seat zone adjacent the head zone, and a knee zone between the seat zone and the foot zone.