One aspect of the present invention relates to amines. A second aspect of
the present invention relates to the use of the amines as inhibitors of a
mammalian anandamide transporter. The compounds of the present invention
will also find use in the treatment of numerous ailments, conditions and
diseases which afflict mammals, including but not limited to asthma,
neuropathic pain, persistent pain, inflammatory pain, hyperactivity,
hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's
syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock,
migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting
syndrome, organ rejection, autoimmune diseases, allergy, arthritis,
Crohn's disease, malignant gliomas, neurodegenerative diseases,
Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention
deficit hyperactivity disorder, premature ejaculation, and stroke.
Another aspect of the present invention relates to combinatorial
libraries of amines, and methods for preparing the libraries.