Certain embodiments of the present invention provide a system, method and computer instructions for compression of four dimensional data. In an embodiment, a system for compression of four dimensional data includes: a compression module configured to compress four dimensional data, wherein the data includes a first three dimensional volume and a second three dimensional volume, and wherein the compression module compresses the data by compressing the first volume and compressing a difference between the first volume and the second volume. In an embodiment, the data may further include a third three dimensional volume and the compression module may further compress the data by compressing a difference between the second volume and the third volume, for example. The system for compression of four dimensional data may also include, an input module(s), a decompression module and an output module(s), for example.