The invention includes compositions comprising substantially purified
serpin that are useful in methods for the treatment and prevention of HIV
infection. The invention also includes methods for the treatment and
prevention of HIV infection comprising contacting a composition of the
invention with a human patient or treating HIV infection by introducing
into a cell susceptible to HIV infection a DNA molecule encoding a
serpin. Additionally, the invention includes antibodies and kits useful
in the detection, treatment, and prevention of HIV infection.