The invention claims compounds of the formula ##STR00001## wherein ##STR00002## is a 5-membered heteroaryl; X is S or O; R.sup.1 is H, alkyl, cycloalkyl, cylcoalkylalkyl-, --CH.sub.2F, --CHF.sub.2, --CF.sub.3, --C(O)alkyl or --C(O)NR.sup.18R.sup.19; R.sup.3 and R.sup.4 H, alkyl, hydroxyalkyl or --C(O)Oalkyl; R.sup.5 and R.sup.6 are H, alkyl, hydroxyalkyl, alkoxyalkyl, mercaptoalkyl, --CH.sub.2F, --CHF.sub.2, --CF.sub.3, --C(O)OH or --C(O)Oalkyl; R.sup.7 is H, alkyl, alkenyl, hydroxyalkyl, cycloalkyl, alkoxyalkyl, aminoalkyl, (R.sup.17-phenyl)alkyl or --CH.sub.2--C(O)--O-alkyl; and R.sup.8 comprises alkyl, heteroaryl, phenyl or cycloalkyl, or heterocycloalkyl, all optionally substituted, or a cycloalkyl- or heterocycloalkyl-substituted amide; or R.sup.7 and R.sup.8 and the nitrogen to which they are attached together form an optionally substituted ring; and the remaining variables are as defined in the specification. Also claimed are pharmaceutical compositions, the use of the compounds as PDE4 inhibitors, and combinations with other actives.