An exemplary embodiment of system, method, and computer accessible medium for magnetic resonance spectroscopic imaging for improving signal-to-noise ratio per unit time and optimizing duty cycle in MRSI and/or for reducing chemical-shift artifacts can be provided. One exemplary embodiment includes forwarding an excitation pulse to the target and acquiring a signal from the target by multiplexing in time and space. Multiplexing in time may involve segmenting a field of view of the at least one portion of the target into a predetermined number of slabs that are acquired sequentially during each repetition time. Multiplexing in space may involve acquiring multiple voxels. Data may be generated based on the acquired signal. A further exemplary embodiment includes providing an excitation pulse to the target and acquiring a signal from the target. The excitation pulse can be a series of cascaded Hadamard pulse components. Data may be generated based on the acquires signal.