The present invention provides a retroviral vector containing a membrane
protein having a hemagglutinin activity. The present inventors
constructed a retroviral vector pseudotyped by the membrane protein
having a hemagglutinin activity. This viral vector showed gene transfer
at a high efficiency into host cells. In particular, it was established
that genes can be transferred thereby at a high efficiency into cells
into which genes can hardly be transferred by the conventional
techniques, for example, blood cells and hematopoietic cells including
hematopoietic stem cells, and mucous cells including mucosa epithelial
cells. The viral vector of the present invention is highly useful as a
vector for gene therapy.