Disclosed herein is a system and method for determining whether to issue an alert to consider prophylaxis (e.g., mechanical and/or pharmacological) with respect to a risk condition (e.g., risk of VTE, DVT and/or PE). One or more sources of patient information are queried to retrieve patient information for a set of patients. From this retrieved patient information, it is determined whether any risk factors of a set of risk factors are satisfied for each such patient. For each patient for which one or more risk factors are satisfied, a respective value and/or classification is assigned to each risk factor. The values and/or classifications are combined to produce a combined value, and it is determined from the combined value whether the patient has the risk condition. If the patient has the risk condition, an alert is issued (e.g., on a display screen) to a health care provider for consideration of prophylaxis.