This invention concerns a compound of formula ##STR00001## a N-oxide, a
pharmaceutically acceptable addition salt, a quaternary amine and a
stereochemically isomeric form thereof, wherein ring A is a 6-membered
heterocycle; R.sup.1 is hydrogen; aryl; formyl; C.sub.1-6alkylcarbonyl;
optionally substituted C.sub.1-6alkyl; C.sub.1-6alkyloxycarbonyl;
optionally substituted C.sub.1-6alkyloxyC.sub.1-6alkylcarbonyl; X is a
direct bond or a linker atom or group; Z is a direct bond or a linker
atom or group; R.sup.2 is hydrogen, C.sub.1-10alkyl, C.sub.2-10alkenyl,
C.sub.2-10alkynyl, a carbocycle or a heterocycle, each of said groups may
optionally be substituted; R.sup.3 is hydrogen; hydroxy; halo; optionally
substituted C.sub.1-6alkyl or C.sub.2-6alkenyl or C.sub.2-6alkynyl;
C.sub.1-6alkyloxy; C.sub.1-6alkylthio; C.sub.1-6alkyloxycarbonyl;
C.sub.1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or
di(C.sub.1-6alkyl)amino; polyhaloC.sub.1-6alkyl;
polyhaloC.sub.1-6alkyloxy; polyhaloC.sub.1-6alkylthio; R.sup.21;
R.sup.21--C.sub.1-6alkyl; R.sup.21--O--; R.sup.21--S--;
R.sup.21--C(.dbd.O)--; R.sup.21--S(.dbd.O).sub.p--;
R.sup.7--S(.dbd.O).sub.p--; R.sup.7--S(.dbd.O).sub.p--NH--;
R.sup.21--S(.dbd.O).sub.p--NH--; R.sup.7--C(.dbd.O)--; --NHC(.dbd.O)H;
--C(.dbd.O)NHNH.sub.2; R.sup.7--C(.dbd.O)--NH--;
R.sup.21--C(.dbd.O)--NH--; --C(.dbd.NH)R.sup.7--C(.dbd.NH)R.sup.21;
R.sup.4 is an optionally substituted heterocycle provided that
--X--R.sup.2 and/or R.sup.3 is other than hydrogen; their use,
pharmaceutical compositions comprising them and processes for their
preparation.
