A method for volume based registration of images is presented. The method includes receiving a first image data set and at least one other image data set. Further the method includes identifying a first image slice in the at least one other image data set corresponding to the first image data set. The method also includes selecting a first point of interest on at least one of the first image data set or the first image slice in the at least one other image data set. In addition, the method includes selecting a second point of interest on the other of the first image data set or the first image slice in the at least one other image data set, wherein the second point of interest corresponds to the first point of interest. Moreover, the method includes translating one of the first image data set, the first image slice, or both, in a first direction, a second direction and a third direction to align the first point of interest with the second point of interest. Also, the method includes registering the first image data set and the at least one other image data set. Systems and computer-readable medium that afford functionality of the type defined by this method is also contemplated in conjunction with the present technique.