Compounds of the general formula (I) or a pharmaceutically acceptable
salt, derivative, prodrug or stereoisomer thereof are provided: wherein
the substituent groups defined by R are each independently selected from
the group consisting of H, SiR'.sub.3, SOR', SO.sub.2X, C(.dbd.O)R',
C(.dbd.O)OR', C(.dbd.O)NR', substituted or unsubstituted alkyl,
substituted or unsubstituted alkenyl, substituted or unsubstituted
alkynyl, aryl, heteroaryl or aralkyl; the group R' is selected from
substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl,
substituted or unsubstituted alkynyl, aminoalkyl, aryl, aralkyl and
heterocyclic groups; and the group R'' is selected from the group
consisting of H, OH, OR', OCOR', SH, SR', SOR', SO.sub.2R', NO.sub.2,
NH.sub.2, NHR', N(R').sub.2, NHCOR', N(COR').sub.2, NHSO.sub.2R', CN,
halogen, C(.dbd.O)H, C(.dbd.O)R', CO.sub.2H, CO.sub.2R', CH.sub.2OR,
substituted or unsubstituted alkyl, substituted or unsubstituted
haloalkyl, substituted or unsubstituted alkenyl, substituted or
unsubstituted alkylidene, substituted or unsubstituted alkynyl,
substituted or unsubstituted aryl, substituted or unsubstituted aralkyl
and substituted or unsubstituted heteroaromatic; with the proviso that
the compound is not compound 1, 3 or 4 of U.S. Pat. No. 5,514,708. The
compounds have antitumour activity. A synthetic route is also provided.
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