A compound of formula (I) wherein R.sup.1 represents aryl optionally
substituted by a heterocyclic group or a heterocyclic group optionally
substituted by aryl wherein each aryl or heterocyclic group is optionally
substituted; the group
--(CH.sub.2).sub.m-T-(CH.sub.2).sub.n--U--(CH.sub.2).sub.p-- is attached
at either the 3 or 4 position in the phenyl ring as indicated by the
numbers in formula (I) and represents a group selected from one or more
of the following: O(CH.sub.2).sub.2, O(CH.sub.2).sub.3,
NC(O)NR.sup.4(CH.sub.2).sub.2,
CH.sub.2S(O.sub.2)NR.sup.5(CH.sub.2).sub.2,
CH.sub.2N(R.sup.6)C(O)CH.sub.2,
(CH.sub.2).sub.2N(R.sup.6)C(O)(CH.sub.2).sub.2, C(O)NR.sup.7CH.sub.2,
C(O)NR.sup.7(CH.sub.2).sub.2, and CH.sub.2N(R.sup.6)C(O)CH.sub.2O; V
represents O, S, NR.sup.8 or a single bond; q represents 1, 2, or 3; W
represents O, S, N(R.sup.9)C(O), NR.sup.10, or a single bond; R.sup.2
represents halo, a C.sub.1-4 alkyl group which is optionally substituted
by one or more fluoro, a C.sub.1-4 alkoxy group which is optionally
substituted by one or more fluoro, a C.sub.1-4 acyl group, aryl, an aryl
C.sub.1-4 alkyl group, CN or NO.sub.2; r represents 0, 1, 2 or 3; R.sup.3
halo, a C.sub.1-4 alkyl group which is optionally substutited by one or
more fluoro, a C.sub.1-4 alkoxy group which is optionally substituted by
one or more fluoro, a C.sub.1-4 acyl group, aryl, an aryl C.sub.1-4 alkyl
group, or CN; s represents 0, 1, 2 or 3; and R.sup.4, R.sup.5, R.sup.6,
R.sup.7, R.sup.8, R.sup.9, and R.sup.10 independently represent H, a
C.sub.1-10 alkyl group, aryl or an aryl C.sub.1-4 alkyl group or when m
is O and T represents a group N(R.sup.6)C(O) or a group
(R.sup.5)NS(O.sub.2) then R.sup.1 and R.sup.6 or R.sup.1 and R.sup.5
together with the nitrogen atom to which they are attached represent a
heteroaryl group; with provisos and pharmaceutically acceptable salts
thereof, processes for preparing such compounds, their utility in
treating clinical conditions associated with insulin resistance, methods
for their therapeutic use and pharmaceutical compositions containing
them.
