This invention relates to methods of inhibiting tubulin polymerization and treating cancer and other angiogenesis-related disorders with indole compounds of the formula: ##STR00001## wherein L.sub.1, L.sub.2, R.sub.1, R.sub.2, R.sub.a, R.sub.b, R.sub.c, R.sub.d, and R.sub.e are defined herein.

 
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