A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: ##STR00001## wherein X wherein X is --CF.sub.3, Ar is selected from ##STR00002## and R is selected from ##STR00003## where R' is L-Lys, D-Lys, .beta.-Ala, L-Lue, L-Ile, Phe, SO.sub.2CH.sub.2CH.sub.2NH.sub.2, SO.sub.2NH.sub.2, Asn, Glu or Gyl, and R'' is methyl, ethyl, allyl, CH.sub.2CH.sub.2OH, CH.sub.2CN, CH.sub.2CH.sub.2CN, CH.sub.2CONH.sub.2, ##STR00004##