Articles of footwear are configured to provide functionally correct and predetermined amounts of stretch in functionally correct locations, thus providing comfort to a wearer, while retaining a pleasing aesthetic appearance in use. For example, an article of footwear includes an upper assembly having a first layer coextensive with a second layer. The first layer includes a first material having a first 30% modulus, and the second layer includes at least one first region (e.g., a stretch region) and at least one second region (e.g., a non-stretch region). The at least one first region includes a second material having a second 30% modulus lower than the first 30% modulus. The at least one second region includes a third material having a third 30% modulus higher than both the first 30% modulus and the second 30% modulus.