The invention relates to the field of molecular biology, virology and
medicine and, more specifically, to novel derivatives of
3'-azido-3'-deoxythymidine phosphonates with the following general
formula
##STR00001##
where R=alkyl groups, including those containing halogen atoms, carboxy-,
hydroxy-, alkoxy- and acyloxy- groups as well as substituted
aminocarbonyl groups. The compounds can be used as antiviral agents as
they have low toxicity and can effectively inhibit replication of type 1
immunodeficiency virus in MT-4 cell culture and generate AZT in
mammalians ensuring a gradual increase of its concentration in the blood.