A heat exchange apparatus (10, 10, 10b) for selectively heating and/or cooling a process fluid (38). A process fluid tubing 14 is wrapped around a primary thermally conductive cylinder (12) having a spiral groove (24) therein adapted for closely accepting the process fluid tubing (14) and increasing the area in thermal contact therebetween. The process fluid tubing (14) is a generally chemically inert tubing. The spiral groove (24) supports the process fluid tubing (14) such that the process fluid tubing (14) can be bent in a radius smaller than the natural minimum bend radius of the process fluid tubing (14). Various embodiments have a cooling apparatus (26, 26a) for cooling the process fluid (38). The cooling apparatus (26, 26a) has a outer thermally conductive cylinder (16) or an outer thermal reservoir (50) cooled alternatively by coolant fluid (44) passing through cooling fluid tubing (18), by a plurality of thermoelectric modules (54), or by a combination thereof.