A compound represented by the general formula (I) or a salt thereof: ##STR00001## [T represents oxygen atom and the like; V represents CH.sub.2 and the like; R.sup.01 to R.sup.04 represent hydrogen atom and the like; A represents a linear alkylene group or linear alkenylene group having 2 to 8 carbon atoms and the like; D represents carboxyl group and the like; X represents ethylene group, trimethylene group and the like; E represents --CH(OH)-- group and the like; and W represent --U.sup.1--(R.sup.W1)(R.sup.W2)--U.sup.2--U.sup.3 group (U.sup.1 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; R.sup.W1 and R.sup.W2 represent hydrogen atom and the like; U.sup.2 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; and U.sup.3 represent an alkyl group having 1 to 8 carbon atoms and the like), or a residue of a carbon ring or heterocyclic compound], which can be utilized as an active ingredient of medicaments effective for prophylactic and/or therapeutic treatment of skeletal diseases such as osteoporosis and fracture, glaucoma, ulcerative colitis and the like.